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UTILIZAÇÃO DE PLASMA CONVALESCENTE NO TRATAMENTO DA COVID-19

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15 Julho 2021
UTILIZAÇÃO DE PLASMA CONVALESCENTE NO TRATAMENTO DA COVID-19
O plasma convalescente, que consiste em plasma com elevado teor de anticorpos contra o vírus SARS-CoV-2, obtido a partir de indivíduos recuperados da infeção, tem sido investigado no tratamento da COVID-19, com base em experiência prévia de utilização de plasma com elevado título de anticorpos noutras infeções bacterianas e virais.

Tem vindo a ser utilizado essencialmente em indivíduos hospitalizados, com COVID-19 moderada a grave. Existe, contudo, falta de consenso acerca da utilização do plasma convalescente, uma vez que os ensaios efetuados, revisões sistemáticas e meta-análises reportam resultados contraditórios, sendo incerto que aporte benefício em resultados clinicamente relevantes.

LITERATURA RECOMENDADA

 
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https://journals.lww.com/ccmjournal/Fulltext/2021/07000/Severe_Acute_Respiratory_Syndrome_Coronavirus_2.2.aspx

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https://www.nature.com/articles/s41467-021-23469-2.pdf

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https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7888247/pdf/main.pdf


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https://onlinelibrary.wiley.com/doi/epdf/10.1111/trf.16328