Artigos
VITAMINA D E COVID-19
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O papel da vitamina D como um possível facilitador da resposta imune durante a infeção por SARS-CoV-2 tem vindo a ser analisado na literatura.
Embora alguns estudos observacionais tenham
sugerido uma associação entre o défice de vitamina D e taxas aumentadas de
COVID-19, ou uma maior gravidade desta infeção, a evidência disponível não
permite estabelecer uma relação causal, por ser em alguns casos de baixa
qualidade ou existirem diversos fatores de confusão que afetam os resultados
dos estudos. Outros estudos e meta-análises relatam resultados discrepantes.
Atualmente,
as evidências para apoiar a suplementação de vitamina D para a prevenção ou
tratamento da COVID-19 são inconclusivas. É necessário aguardar os resultados
de estudos clínicos, robustos e corretamente conduzidos, para decidir sobre seu
papel no contexto da pandemia de COVID-19.
LITERATURA RECOMENDADA
COVID-19 rapid guideline: vitamin D. London: National Institute for Health and Care Excellence (UK); 2020 Dec 17.
https://www.nice.org.uk/guidance/ng187/resources/covid19-rapid-guideline-vitamin-d-pdf-66142026720709
https://www.nice.org.uk/guidance/ng187/resources/covid19-rapid-guideline-vitamin-d-pdf-66142026720709
Vitamin D. National Institutes of Health (NIH). Coronavirus Disease 2019 (COVID-19) Treatment Guidelines. Last Updated: April 21, 2021.
https://www.covid19treatmentguidelines.nih.gov/therapies/supplements/vitamin-d
https://www.covid19treatmentguidelines.nih.gov/therapies/supplements/vitamin-d
Raisi-Estabragh Z, Martineau AR, Curtis EM, Moon RJ, Darling A, Lanham-New S, Ward KA, Cooper C, Munroe PB, Petersen SE, Harvey NC. Vitamin D and coronavirus disease 2019 (COVID-19): rapid evidence review. Aging Clin Exp Res. 2021 Jun 12: 1-11. doi: 10.1007/s40520-021-01894-z. Epub ahead of print.
http://link.springer.com/content/pdf/10.1007/s40520-021-01894-z.pdf
http://link.springer.com/content/pdf/10.1007/s40520-021-01894-z.pdf
Grove A, Osokogu O, Al-Khudairy L, Mehrabian A, Zanganeh M, Brown A, Court R, Taylor-Phillips S, Uthman OA, McCarthy N, Kumar S, Clarke A. Association between vitamin D supplementation or serum vitamin D level and susceptibility to SARS-CoV-2 infection or COVID-19 including clinical course, morbidity and mortality outcomes? A systematic review. BMJ Open. 2021 May 28; 11(5): e043737. doi: 10.1136/bmjopen-2020-043737.
https://bmjopen.bmj.com/content/bmjopen/11/5/e043737.full.pdf
https://bmjopen.bmj.com/content/bmjopen/11/5/e043737.full.pdf
Bassatne A, Basbous M, Chakhtoura M, El Zein O, Rahme M, El-Hajj Fuleihan G. The link between COVID-19 and VItamin D (VIVID): A systematic review and meta- analysis. Metabolism. 2021 Jun; 119:1 54753. doi: 10.1016/j.metabol.2021.154753. Epub 2021 Mar 24.
https://www.metabolismjournal.com/action/showPdf?pii=S0026-0495%2821%2900053-6
https://www.metabolismjournal.com/action/showPdf?pii=S0026-0495%2821%2900053-6
Petrelli F, Luciani A, Perego G, Dognini G, Colombelli PL, Ghidini A. Therapeutic and prognostic role of vitamin D for COVID-19 infection: A systematic review and meta-analysis of 43 observational studies. J Steroid Biochem Mol Biol. 2021 Mar 25; 211: 105883. Epub ahead of print. DOI 10.1016/j.jsbmb.2021.105883.
https://www.sciencedirect.com/science/article/pii/S0960076021000765?via%3Dihub
https://www.sciencedirect.com/science/article/pii/S0960076021000765?via%3Dihub
Entrenas Castillo M, Entrenas Costa LM, Vaquero Barrios JM, Alcalá Díaz JF, López Miranda J, Bouillon R, Quesada Gomez JM. "Effect of calcifediol treatment and best available therapy versus best available therapy on intensive care unit admission and mortality among patients hospitalized for COVID-19: A pilot randomized clinical study". J Steroid Biochem Mol Biol. 2020 Oct;203:105751. doi: 10.1016/j.jsbmb.2020.105751. Epub 2020 Aug 29.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7456194/pdf/main.pdf
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7456194/pdf/main.pdf
Murai IH, Fernandes AL, Sales LP, Pinto AJ, Goessler KF, Duran CSC, Silva CBR, Franco AS, Macedo MB, Dalmolin HHH, Baggio J, Balbi GGM, Reis BZ, Antonangelo L, Caparbo VF, Gualano B, Pereira RMR. Effect of a Single High Dose of Vitamin D3 on Hospital Length of Stay in Patients With Moderate to Severe COVID-19: A Randomized Clinical Trial. JAMA. 2021 Mar 16; 325(11): 1053-1060. doi: 10.1001/jama.2020.26848.
http://jamanetwork.com/journals/jama/fullarticle/2776738
http://jamanetwork.com/journals/jama/fullarticle/2776738